| SP | Sanchez, S.Sanchez, Sixto | 26 | Cubs | R | 96 | 27 | 27 | 19 | 1 | 3.27 | .257 | 1.02 | 7.1 | 2.0 | 7.0 | 189.2 | 150 | 76 | 69 | 22 | 43 | 148 | 3 | 0 | 0 | 2 | 19 | 4 | 2 | 3.69 |
| SP | Fernandez, J.Fernandez, Jose | 33 | Cubs | R | 99 | 27 | 27 | 14 | 8 | 3.36 | .274 | 1.11 | 7.8 | 2.3 | 9.7 | 203.2 | 175 | 81 | 76 | 32 | 51 | 219 | 13 | 0 | 0 | 0 | 18 | 5 | 2 | 3.72 |
| SP | Valdez, F.Valdez, Framber # | 31 | Astros | L | 98 | 27 | 27 | 15 | 6 | 2.88 | .243 | 0.95 | 5.4 | 3.1 | 9.3 | 172.0 | 104 | 62 | 55 | 12 | 59 | 178 | 0 | 0 | 0 | 0 | 18 | 3 | 12 | 2.92 |
| SP | Bieber, S.Bieber, Shane + | 30 | Astros | R | 100 | 27 | 27 | 11 | 8 | 3.33 | .269 | 1.06 | 6.9 | 2.7 | 11.2 | 186.1 | 142 | 72 | 69 | 23 | 55 | 231 | 2 | 0 | 0 | 2 | 17 | 9 | 5 | 3.16 |
| SP | Howard, S.Howard, Spencer | 28 | Cardinals | R | 94 | 26 | 25 | 12 | 9 | 3.63 | .279 | 1.14 | 7.0 | 3.2 | 9.7 | 136.1 | 106 | 60 | 55 | 16 | 49 | 146 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 3.53 |
| RP | Cabrera, G.Cabrera, Genesis | 28 | Cardinals | L | 100 | 69 | 0 | 10 | 0 | 2.32 | .278 | 1.13 | 5.1 | 5.1 | 10.8 | 112.1 | 63 | 32 | 29 | 7 | 64 | 134 | 0 | 1 | 1 | 0 | 0 | 3 | 6 | 3.21 |
| CL | Williams, D.Williams, Devin + | 30 | Astros | R | 100 | 53 | 0 | 0 | 1 | 1.63 | .251 | 0.99 | 4.6 | 4.4 | 13.6 | 49.2 | 25 | 11 | 9 | 2 | 24 | 74 | 0 | 43 | 5 | 0 | 0 | 1 | 1 | 2.04 |