| SP | Chirinos, Y.Chirinos, Yonny | 33 | Devil Rays | R | 85 | 40 | 40 | 23 | 8 | 3.35 | .282 | 1.16 | 8.2 | 2.2 | 8.8 | 231.1 | 211 | 94 | 86 | 31 | 57 | 227 | 1 | 0 | 0 | 1 | 26 | 5 | 3 | 3.58 |
| SP | Rodriguez, E.Rodriguez, Eduardo | 34 | Orioles | L | 52 | 40 | 40 | 16 | 15 | 5.06 | .321 | 1.39 | 9.0 | 3.5 | 10.0 | 233.0 | 233 | 135 | 131 | 52 | 90 | 258 | 0 | 0 | 0 | 0 | 21 | 7 | 2 | 4.94 |
| SP | Glasnow, T.Glasnow, Tyler # | 33 | Blue Jays | R | 99 | 40 | 40 | 14 | 12 | 4.47 | .289 | 1.16 | 8.3 | 2.2 | 10.0 | 229.2 | 210 | 119 | 114 | 45 | 57 | 255 | 0 | 0 | 0 | 0 | 20 | 13 | 6 | 4.24 |
| RP | Luciano, E.Luciano, Elvis | 27 | Yankees | R | 97 | 89 | 0 | 21 | 6 | 2.71 | .260 | 1.03 | 6.5 | 2.8 | 10.4 | 173.0 | 124 | 55 | 52 | 20 | 54 | 200 | 0 | 8 | 0 | 0 | 0 | 4 | 6 | 3.20 |
| RP | Hernandez, D.Hernandez, Darwinzon | 30 | Red Sox | L | 100 | 93 | 0 | 6 | 5 | 4.14 | .258 | 1.04 | 6.0 | 3.5 | 13.5 | 104.1 | 69 | 49 | 48 | 15 | 40 | 156 | 0 | 11 | 2 | 0 | 0 | 0 | 1 | 3.03 |
| RP | Pannone, T.Pannone, Thomas | 33 | Devil Rays | L | 67 | 79 | 0 | 9 | 5 | 4.72 | .305 | 1.29 | 8.7 | 2.9 | 8.5 | 145.0 | 140 | 84 | 76 | 29 | 47 | 137 | 0 | 15 | 4 | 0 | 0 | 4 | 7 | 4.77 |