| SP | Scherzer, M.Scherzer, Max | 33 | Ducks | R | 98 | 33 | 33 | 13 | 9 | 2.77 | .276 | 1.13 | 7.3 | 2.8 | 10.1 | 237.1 | 193 | 75 | 73 | 23 | 75 | 266 | 4 | 0 | 0 | 0 | 27 | 4 | 1 | 3.02 |
| SP | Kershaw, C.Kershaw, Clayton | 28 | Cowboys | L | 99 | 33 | 33 | 13 | 11 | 3.70 | .287 | 1.18 | 9.2 | 1.4 | 9.7 | 207.0 | 211 | 90 | 85 | 28 | 33 | 224 | 3 | 0 | 0 | 0 | 19 | 6 | 2 | 3.16 |
| SP | Hernandez, F.Hernandez, Felix # | 28 | Athletics | R | 88 | 33 | 32 | 14 | 8 | 4.39 | .303 | 1.29 | 8.8 | 2.9 | 9.2 | 194.2 | 189 | 98 | 95 | 27 | 62 | 198 | 1 | 0 | 0 | 1 | 20 | 3 | 18 | 3.77 |
| SP | Clevinger, M.Clevinger, Mike | 28 | Grasshoppers | R | 75 | 33 | 33 | 16 | 12 | 5.14 | .328 | 1.45 | 9.2 | 3.8 | 9.7 | 194.1 | 199 | 114 | 111 | 40 | 82 | 209 | 0 | 0 | 0 | 0 | 14 | 4 | 0 | 4.86 |
| RP | Robertson, D.Robertson, David | 32 | Athletics | R | 85 | 80 | 0 | 11 | 1 | 2.94 | .230 | 0.88 | 4.8 | 3.1 | 10.9 | 104.0 | 56 | 34 | 34 | 10 | 36 | 126 | 0 | 4 | 1 | 0 | 0 | 1 | 4 | 2.89 |
| CL | Doolittle, S.Doolittle, Sean | 31 | Athletics | L | 99 | 73 | 0 | 4 | 6 | 3.30 | .322 | 1.37 | 8.4 | 4.1 | 10.7 | 73.2 | 68 | 27 | 27 | 9 | 33 | 87 | 0 | 47 | 5 | 0 | 0 | 4 | 1 | 3.74 |
| CL | Betances, D.Betances, Dellin | 26 | Mountain Lions | R | 96 | 62 | 0 | 8 | 7 | 1.82 | .277 | 1.12 | 5.8 | 4.3 | 9.0 | 74.0 | 48 | 15 | 15 | 6 | 35 | 74 | 0 | 26 | 0 | 0 | 0 | 2 | 1 | 3.55 |
| CL | Jansen, K.Jansen, Kenley # | 28 | Suns | R | 98 | 66 | 0 | 7 | 8 | 4.48 | .282 | 1.14 | 7.7 | 2.6 | 9.4 | 70.1 | 60 | 37 | 35 | 11 | 20 | 73 | 0 | 35 | 6 | 0 | 0 | 3 | 4 | 3.94 |