| SP | Martinez, P.Martinez, Pedro | 29 | Wolves | R | 100 | 36 | 36 | 21 | 8 | 2.53 | .262 | 1.04 | 7.5 | 1.8 | 9.8 | 278.0 | 232 | 91 | 78 | 30 | 57 | 303 | 10 | 0 | 0 | 2 | 28 | 7 | 3 | 2.91 |
| SP | Hernandez, F.Hernandez, Felix | 19 | Devils | R | 96 | 35 | 35 | 18 | 12 | 3.80 | .296 | 1.23 | 7.7 | 3.3 | 6.9 | 248.2 | 213 | 108 | 105 | 28 | 92 | 191 | 9 | 0 | 0 | 2 | 18 | 8 | 6 | 4.14 |
| SP | Johnson, R.Johnson, Randy | 38 | Banditos | L | 97 | 34 | 34 | 21 | 8 | 3.52 | .280 | 1.13 | 7.3 | 2.9 | 10.2 | 238.0 | 194 | 97 | 93 | 26 | 76 | 271 | 2 | 0 | 0 | 0 | 24 | 7 | 8 | 3.19 |
| SP | Schilling, C.Schilling, Curt # | 36 | Americans | R | 93 | 35 | 35 | 19 | 11 | 3.52 | .280 | 1.12 | 8.0 | 2.1 | 9.1 | 243.0 | 216 | 97 | 95 | 31 | 57 | 246 | 7 | 0 | 0 | 2 | 21 | 10 | 4 | 3.46 |
| CL | Papelbon, J.Papelbon, Jonathan | 26 | Bulls | R | 93 | 87 | 0 | 9 | 6 | 2.99 | .262 | 1.02 | 6.9 | 2.3 | 9.4 | 105.1 | 80 | 36 | 35 | 17 | 27 | 110 | 0 | 32 | 4 | 0 | 0 | 5 | 1 | 3.92 |
| CL | Benitez, A.Benitez, Armando | 32 | Slammers | R | 91 | 75 | 0 | 3 | 4 | 2.58 | .288 | 1.20 | 5.9 | 5.0 | 5.7 | 76.2 | 50 | 25 | 22 | 5 | 42 | 48 | 0 | 37 | 7 | 0 | 0 | 1 | 0 | 4.29 |