| SP | Verlander, J.Verlander, Justin | 36 | Spiders | R | 32.0 | 4 | 4 | 4 | 0 | 2.37 | .242 | 0.96 | 6.9 | 1.8 | 9.3 | 30.1 | 23 | 8 | 8 | 1 | 6 | 31 | 1 | 0 | 0 | 1 | 3 | 0 | 0 | 1.97 |
| SP | deGrom, J.deGrom, Jacob $$ | 33 | Americans | R | 22.0 | 4 | 4 | 3 | 1 | 2.67 | .202 | 0.76 | 5.4 | 1.5 | 6.3 | 30.1 | 18 | 9 | 9 | 5 | 5 | 21 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 4.27 |
| SP | Caldwell, R.Caldwell, Ray | 26 | Frogs | R | 20.0 | 4 | 4 | 3 | 1 | 2.60 | .284 | 1.19 | 7.3 | 3.7 | 2.0 | 27.2 | 22 | 11 | 8 | 0 | 11 | 6 | 0 | 0 | 0 | 0 | 4 | 0 | 1 | 3.78 |
| SP | Koufax, S.Koufax, Sandy $ | 30 | Mets | L | 18.0 | 4 | 4 | 2 | 2 | 2.70 | .297 | 1.23 | 7.8 | 3.3 | 9.3 | 30.0 | 26 | 10 | 9 | 3 | 11 | 31 | 2 | 0 | 0 | 1 | 2 | 1 | 0 | 3.43 |
| SP | Marichal, J.Marichal, Juan | 29 | Mets | R | 18.0 | 4 | 4 | 2 | 1 | 2.96 | .274 | 1.10 | 8.7 | 1.3 | 5.3 | 27.1 | 26 | 10 | 9 | 2 | 4 | 16 | 2 | 0 | 0 | 1 | 3 | 1 | 0 | 3.33 |