| SP | Verlander, J.Verlander, Justin | 28 | DET | R | 68.0 | 12 | 12 | 8 | 0 | 2.83 | .279 | 1.16 | 7.6 | 2.8 | 7.2 | 86.0 | 73 | 27 | 27 | 5 | 27 | 69 | 2 | 0 | 0 | 1 | 9 | 0 | 1 | 3.09 |
| SP | Zambrano, C.Zambrano, Carlos | 24 | CHC | R | 57.0 | 12 | 12 | 8 | 1 | 3.55 | .322 | 1.40 | 7.3 | 5.4 | 8.4 | 78.2 | 63 | 32 | 31 | 5 | 47 | 73 | 1 | 0 | 0 | 0 | 7 | 2 | 3 | 3.85 |
| SP | Skubal, T.Skubal, Tarik # | 28 | DET | L | 49.0 | 12 | 12 | 7 | 2 | 3.63 | .274 | 1.13 | 8.4 | 1.8 | 10.8 | 79.1 | 74 | 33 | 32 | 11 | 16 | 95 | 0 | 0 | 0 | 0 | 7 | 0 | 1 | 3.01 |
| SP | Gonsolin, T.Gonsolin, Tony | 28 | LAD | R | 45.0 | 12 | 12 | 5 | 4 | 1.98 | .256 | 0.99 | 5.6 | 3.4 | 6.9 | 72.2 | 45 | 20 | 16 | 7 | 27 | 55 | 0 | 0 | 0 | 0 | 6 | 3 | 1 | 3.99 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke | 27 | Red Sox 07-18 | R | 44.0 | 12 | 12 | 6 | 2 | 3.45 | .325 | 1.42 | 9.3 | 3.5 | 7.4 | 78.1 | 81 | 32 | 30 | 5 | 30 | 64 | 0 | 0 | 0 | 0 | 9 | 2 | 3 | 3.42 |
| SP | Hendricks, K.Hendricks, Kyle | 26 | CHC | R | 38.0 | 12 | 12 | 6 | 2 | 4.27 | .320 | 1.41 | 8.7 | 4.0 | 8.4 | 78.0 | 75 | 39 | 37 | 6 | 35 | 73 | 0 | 0 | 0 | 0 | 6 | 0 | 2 | 3.47 |