| SP | Schmidt, J.Schmidt, Jason | 30 | Demons | R | 99 | 29 | 29 | 16 | 8 | 3.78 | .299 | 1.25 | 8.0 | 3.3 | 9.3 | 209.1 | 185 | 92 | 88 | 19 | 76 | 216 | 5 | 0 | 0 | 0 | 18 | 7 | 2 | 3.31 |
| SP | Martinez, P.Martinez, Pedro | 29 | Cougars | R | 100 | 29 | 29 | 15 | 9 | 4.23 | .291 | 1.21 | 8.1 | 2.8 | 10.7 | 214.2 | 193 | 102 | 101 | 35 | 66 | 255 | 8 | 0 | 0 | 2 | 14 | 5 | 0 | 3.74 |
| SP | Lincecum, T.Lincecum, Tim | 25 | Rhinos | R | 92 | 29 | 29 | 12 | 8 | 3.86 | .306 | 1.29 | 7.8 | 3.8 | 8.0 | 186.1 | 161 | 83 | 80 | 12 | 79 | 165 | 2 | 0 | 0 | 1 | 17 | 6 | 9 | 3.44 |
| SP | Vazquez, J.Vazquez, Javier | 33 | Gators | R | 86 | 28 | 28 | 11 | 8 | 4.42 | .303 | 1.27 | 8.8 | 2.6 | 9.3 | 197.1 | 193 | 101 | 97 | 25 | 57 | 204 | 2 | 0 | 0 | 0 | 14 | 7 | 3 | 3.55 |
| SP | Hernandez, F.Hernandez, Felix | 19 | Crabs | R | 96 | 29 | 29 | 12 | 12 | 3.17 | .310 | 1.32 | 8.2 | 3.7 | 6.7 | 207.1 | 189 | 84 | 73 | 15 | 84 | 153 | 5 | 0 | 0 | 0 | 24 | 6 | 5 | 3.77 |
| RP | Wuertz, M.Wuertz, Michael | 31 | Cougars | R | 73 | 72 | 0 | 9 | 2 | 3.63 | .309 | 1.29 | 7.8 | 3.8 | 10.3 | 62.0 | 54 | 27 | 25 | 4 | 26 | 71 | 0 | 6 | 4 | 0 | 0 | 3 | 5 | 2.95 |
| RP | Williamson, S.Williamson, Scott | 26 | Nightmares | R | 52 | 68 | 0 | 7 | 6 | 4.03 | .272 | 1.07 | 6.4 | 3.3 | 9.6 | 91.2 | 65 | 41 | 41 | 6 | 33 | 97 | 0 | 6 | 2 | 0 | 0 | 5 | 7 | 2.98 |
| RP | Papelbon, J.Papelbon, Jonathan | 26 | Nightmares | R | 93 | 68 | 0 | 7 | 4 | 2.90 | .270 | 1.08 | 7.1 | 2.7 | 10.2 | 105.2 | 83 | 35 | 34 | 8 | 31 | 119 | 0 | 1 | 4 | 0 | 0 | 3 | 0 | 2.70 |
| CL | Rivera, M.Rivera, Mariano | 39 | Rhinos | R | 96 | 63 | 0 | 3 | 6 | 2.22 | .225 | 0.87 | 6.7 | 1.2 | 9.7 | 69.0 | 51 | 17 | 17 | 6 | 9 | 74 | 0 | 37 | 5 | 0 | 0 | 0 | 1 | 2.38 |