| SP | Rodon, C.Rodon, Carlos $$ | 31 | White Sox | L | 142.0 | 40 | 40 | 19 | 9 | 3.21 | .290 | 1.18 | 7.3 | 3.3 | 11.1 | 218.2 | 177 | 87 | 78 | 19 | 81 | 270 | 0 | 0 | 0 | 0 | 20 | 10 | 7 | 2.91 |
| SP | Humber, B.Humber, Bill # $$ | 25 | Rays | L | 136.0 | 35 | 35 | 19 | 9 | 3.85 | .274 | 1.09 | 7.4 | 2.4 | 6.4 | 247.2 | 204 | 108 | 106 | 35 | 66 | 176 | 10 | 0 | 0 | 4 | 18 | 10 | 10 | 4.34 |
| SP | Johnson, G.Johnson, Greg $$ | 24 | Angels | L | 120.0 | 35 | 35 | 19 | 10 | 3.86 | .296 | 1.23 | 7.9 | 3.1 | 6.9 | 233.0 | 205 | 103 | 100 | 39 | 81 | 179 | 2 | 0 | 0 | 0 | 22 | 8 | 4 | 4.79 |
| SP | Carlin, S.Carlin, Steven $$ | 23 | Blue Jays | L | 111.0 | 35 | 35 | 20 | 8 | 4.72 | .340 | 1.50 | 9.2 | 4.3 | 7.5 | 242.0 | 248 | 132 | 127 | 34 | 116 | 203 | 4 | 0 | 0 | 0 | 17 | 10 | 2 | 4.71 |
| SP | Cuizon, N.Cuizon, Noel $$ | 25 | Mariners | R | 109.0 | 36 | 36 | 15 | 8 | 3.73 | .310 | 1.31 | 8.0 | 3.8 | 10.0 | 212.1 | 189 | 97 | 88 | 24 | 90 | 236 | 1 | 0 | 0 | 1 | 22 | 7 | 3 | 3.62 |
| SP | Berrios, J.Berrios, Jose $$ | 30 | Twins | R | 108.0 | 37 | 37 | 16 | 14 | 3.88 | .278 | 1.13 | 7.6 | 2.6 | 10.1 | 243.2 | 206 | 115 | 105 | 35 | 69 | 273 | 3 | 0 | 0 | 1 | 20 | 7 | 4 | 3.56 |
| SP | Lefebvre, L.Lefebvre, Leo # $$ | 27 | Royals | L | 106.0 | 37 | 37 | 18 | 11 | 4.22 | .298 | 1.23 | 8.5 | 2.5 | 6.6 | 226.0 | 214 | 107 | 106 | 25 | 63 | 166 | 5 | 0 | 0 | 1 | 18 | 11 | 7 | 3.95 |
| SP | McCullers, L.McCullers, Lance $$ | 31 | Astros | R | 106.0 | 34 | 34 | 14 | 10 | 3.35 | .276 | 1.09 | 6.3 | 3.6 | 10.0 | 206.2 | 144 | 85 | 77 | 22 | 82 | 230 | 0 | 0 | 0 | 0 | 21 | 10 | 11 | 3.50 |