| SP | Santana, J.Santana, Johan # | 25 | Sluggers | L | 100 | 30 | 30 | 21 | 4 | 2.81 | .248 | 0.98 | 6.7 | 2.1 | 9.1 | 214.2 | 160 | 68 | 67 | 18 | 51 | 216 | 1 | 0 | 0 | 1 | 22 | 1 | 1 | 2.80 |
| SP | Halladay, R.Halladay, Roy | 28 | Monarchs | R | 87 | 30 | 30 | 13 | 10 | 3.37 | .273 | 1.11 | 8.4 | 1.6 | 7.1 | 213.2 | 199 | 87 | 80 | 31 | 39 | 168 | 5 | 0 | 0 | 2 | 18 | 3 | 6 | 3.91 |
| SP | Lincecum, T.Lincecum, Tim | 25 | Plunder | R | 92 | 29 | 29 | 10 | 15 | 3.38 | .281 | 1.14 | 6.9 | 3.4 | 9.0 | 205.1 | 157 | 82 | 77 | 19 | 77 | 206 | 4 | 0 | 0 | 1 | 18 | 7 | 3 | 3.42 |
| SP | Schilling, C.Schilling, Curt | 36 | Reapers | R | 93 | 29 | 29 | 11 | 12 | 3.61 | .279 | 1.13 | 8.1 | 2.1 | 9.5 | 229.2 | 206 | 98 | 92 | 22 | 53 | 241 | 6 | 0 | 0 | 2 | 14 | 8 | 3 | 2.94 |
| RP | Soriano, R.Soriano, Rafael | 24 | Frogs | R | 97 | 81 | 0 | 13 | 2 | 3.88 | .311 | 1.34 | 9.3 | 2.7 | 9.5 | 118.1 | 122 | 52 | 51 | 9 | 36 | 125 | 0 | 8 | 2 | 0 | 0 | 2 | 0 | 2.84 |
| CL | Papelbon, J.Papelbon, Jonathan | 26 | Mountain Lions | R | 93 | 67 | 0 | 8 | 3 | 2.60 | .258 | 1.03 | 6.8 | 2.5 | 9.3 | 79.2 | 60 | 25 | 23 | 3 | 22 | 82 | 0 | 30 | 2 | 0 | 0 | 1 | 1 | 2.29 |
| CL | Rivera, M.Rivera, Mariano | 39 | Sluggers | R | 96 | 64 | 0 | 3 | 3 | 4.45 | .287 | 1.18 | 8.1 | 2.6 | 9.9 | 58.2 | 52 | 31 | 29 | 10 | 17 | 64 | 0 | 40 | 3 | 0 | 0 | 2 | 1 | 4.02 |