| SP | Santana, J.Santana, Johan | 25 | Outlaws | L | 100 | 26 | 26 | 10 | 10 | 3.83 | .303 | 1.27 | 8.7 | 2.7 | 8.7 | 181.0 | 175 | 78 | 77 | 19 | 54 | 174 | 4 | 0 | 0 | 1 | 19 | 7 | 7 | 3.45 |
| SP | Martinez, P.Martinez, Pedro | 29 | Chieftains | R | 100 | 26 | 26 | 12 | 6 | 3.29 | .280 | 1.14 | 7.8 | 2.5 | 10.0 | 178.0 | 154 | 67 | 65 | 18 | 49 | 197 | 7 | 0 | 0 | 3 | 16 | 5 | 3 | 3.01 |
| SP | Johnson, R.Johnson, Randy # | 38 | Cowboys | L | 97 | 26 | 26 | 14 | 7 | 3.99 | .301 | 1.27 | 8.9 | 2.6 | 9.3 | 180.2 | 177 | 82 | 80 | 24 | 52 | 185 | 4 | 0 | 0 | 1 | 17 | 4 | 3 | 3.61 |
| SP | Halladay, R.Halladay, Roy | 28 | Cowboys | R | 87 | 24 | 24 | 12 | 7 | 3.96 | .309 | 1.32 | 9.5 | 2.4 | 6.2 | 170.2 | 179 | 84 | 75 | 22 | 46 | 117 | 6 | 0 | 0 | 2 | 13 | 4 | 1 | 4.19 |
| CL | Rivera, M.Rivera, Mariano | 39 | Jokers | R | 96 | 49 | 0 | 2 | 2 | 2.22 | .266 | 1.03 | 7.9 | 1.5 | 8.4 | 48.2 | 42 | 14 | 12 | 2 | 8 | 45 | 0 | 32 | 3 | 0 | 0 | 3 | 0 | 2.35 |
| CL | Papelbon, J.Papelbon, Jonathan | 26 | Gators | R | 93 | 49 | 0 | 2 | 6 | 3.83 | .256 | 1.03 | 6.4 | 2.9 | 8.1 | 49.1 | 35 | 21 | 21 | 3 | 16 | 44 | 0 | 29 | 3 | 0 | 0 | 0 | 0 | 2.98 |
| CL | Benitez, A.Benitez, Armando | 32 | Elephants | R | 91 | 54 | 0 | 4 | 7 | 3.32 | .293 | 1.22 | 7.3 | 3.8 | 5.4 | 78.2 | 63 | 29 | 29 | 5 | 33 | 47 | 0 | 13 | 6 | 0 | 0 | 2 | 0 | 3.97 |