Playoff Series Breakdown
| Play-In Round: Cardinals @ Phillies | ||
| 1 | Cardinals 4, Phillies 2 | WP: Mikolas LP: Eickhoff |
| Cardinals Win Series 1-0 | ||
| Play-In Round: Cardinals @ Twins | ||
| 1 | Twins 2, Cardinals 1 | WP: Pineda LP: Flaherty |
| Twins Win Series 1-0 | ||
| Play-In Round: Phillies @ Twins | ||
| 1 | Twins 4, Phillies 0 | WP: Odorizzi LP: Vargas |
| Twins Win Series 1-0 | ||
| First Round Playoff: Twins @ Yankees | ||
| 1 | Yankees 4, Twins 0 | WP: Severino LP: Berrios |
| 2 | Yankees 8, Twins 2 | WP: Tanaka LP: Odorizzi |
| Yankees Win Series 2-0 | ||
| First Round Playoff: Brewers @ Giants | ||
| 1 | Giants 2, Brewers 1 | WP: Abad LP: Hader |
| 2 | Giants 10, Brewers 2 | WP: Bumgarner LP: Gonzalez |
| Giants Win Series 2-0 | ||
| First Round Playoff: Cardinals @ Cubs | ||
| 1 | Cubs 11, Cardinals 2 | WP: Hendricks LP: Wainwright |
| 2 | Cubs 3, Cardinals 1 | WP: Darvish LP: Mikolas |
| Cubs Win Series 2-0 | ||
| Second Round Playoff: Nationals @ Giants | ||
| 1 | Giants 5, Nationals 3 | WP: Samardzija LP: Scherzer |
| 2 | Nationals 10, Giants 3 | WP: Sipp LP: Abad |
| 3 | Nationals 2, Giants 1 | WP: Hudson LP: Bumgarner |
| 4 | Nationals 7, Giants 2 | WP: Corbin LP: Pomeranz |
| Nationals Win Series 3-1 | ||
| Second Round Playoff: Cubs @ Yankees | ||
| 1 | Yankees 6, Cubs 5 | WP: Green LP: Kimbrel |
| 2 | Yankees 12, Cubs 4 | WP: Chapman LP: Cishek |
| 3 | Yankees 4, Cubs 3 | WP: Britton LP: Lester |
| Yankees Win Series 3-0 | ||
| Third Round Playoff: Yankees @ Indians | ||
| 1 | Indians 7, Yankees 0 | WP: Kluber LP: Severino |
| 2 | Yankees 8, Indians 6 | WP: Tanaka LP: Clevinger |
| 3 | Yankees 2, Indians 1 | WP: Chapman LP: Bauer |
| 4 | Yankees 7, Indians 2 | WP: Sabathia LP: Perez |
| 5 | Indians 8, Yankees 7 | WP: Clippard LP: Chapman |
| 6 | Indians 5, Yankees 1 | WP: Clevinger LP: Tanaka |
| 7 | Indians 8, Yankees 6 | WP: Civale LP: Britton |
| Indians Win Series 4-3 | ||
| Third Round Playoff: Nationals @ Dodgers | ||
| 1 | Dodgers 2, Nationals 1 | WP: Buehler LP: Scherzer |
| 2 | Nationals 4, Dodgers 0 | WP: Strasburg LP: Hill |
| 3 | Nationals 7, Dodgers 2 | WP: Hudson LP: Kershaw |
| 4 | Nationals 7, Dodgers 2 | WP: Corbin LP: Gonsolin |
| 5 | Dodgers 9, Nationals 4 | WP: Ryu LP: Scherzer |
| 6 | Dodgers 2, Nationals 1 | WP: Baez LP: Strickland |
| 7 | Nationals 2, Dodgers 1 | WP: Hudson LP: Kershaw |
| Nationals Win Series 4-3 | ||
| World Series: Nationals @ Indians | ||
| 1 | Indians 4, Nationals 3 | WP: Kluber LP: Scherzer |
| 2 | Indians 7, Nationals 3 | WP: Ramirez LP: Strasburg |
| 3 | Nationals 9, Indians 4 | WP: Hudson LP: Bauer |
| 4 | Indians @ Nationals | |
| 5 | Indians @ Nationals | |
| 6 | Nationals @ Indians | |
| 7 | Nationals @ Indians | |
| Indians Lead Series 2-1 | ||
