| SP | Oswalt, R.Oswalt, Roy # | 32 | Astros | R | 93 | 9 | 9 | 5 | 4 | 3.38 | .249 | 0.98 | 8.3 | 0.6 | 7.5 | 61.1 | 56 | 23 | 23 | 7 | 4 | 51 | 3 | 0 | 0 | 1 | 7 | 1 | 0 | 3.07 |
| SP | Martinez, P.Martinez, Pedro | 38 | Red Sox | R | 95 | 8 | 8 | 4 | 3 | 4.88 | .375 | 1.71 | 11.0 | 4.4 | 6.7 | 59.0 | 72 | 33 | 32 | 4 | 29 | 44 | 0 | 0 | 0 | 0 | 3 | 5 | 0 | 4.12 |
| SP | Cain, M.Cain, Matt | 25 | Giants | R | 98 | 8 | 8 | 6 | 1 | 2.62 | .306 | 1.27 | 6.2 | 5.3 | 7.0 | 58.1 | 40 | 17 | 17 | 4 | 34 | 45 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 4.26 |
| SP | Burnett, A.Burnett, A.J. | 32 | Marlins | R | 74 | 8 | 8 | 2 | 2 | 3.10 | .281 | 1.14 | 7.8 | 2.5 | 9.2 | 58.0 | 50 | 20 | 20 | 4 | 16 | 59 | 0 | 0 | 0 | 0 | 6 | 2 | 2 | 2.79 |
| SP | Duchscherer, J.Duchscherer, Justin | 32 | A's | R | 92 | 8 | 8 | 3 | 4 | 3.28 | .270 | 1.09 | 7.9 | 2.1 | 6.6 | 57.2 | 50 | 22 | 21 | 6 | 13 | 42 | 3 | 0 | 0 | 0 | 5 | 1 | 0 | 3.63 |
| SP | Lilly, T.Lilly, Ted | 33 | A's | L | 88 | 8 | 8 | 4 | 2 | 2.35 | .252 | 0.99 | 6.3 | 2.7 | 5.2 | 57.1 | 40 | 15 | 15 | 4 | 17 | 33 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 3.70 |
| SP | Hamels, C.Hamels, Cole | 26 | Phillies | L | 89 | 8 | 8 | 4 | 4 | 2.83 | .265 | 1.06 | 6.6 | 3.0 | 8.1 | 57.1 | 42 | 20 | 18 | 6 | 19 | 51 | 3 | 0 | 0 | 3 | 6 | 1 | 0 | 3.63 |
| SP | Hernandez, F.Hernandez, Felix | 23 | Mariners | R | 96 | 8 | 8 | 3 | 3 | 3.95 | .293 | 1.18 | 8.7 | 1.9 | 8.8 | 57.0 | 55 | 25 | 25 | 1 | 12 | 56 | 1 | 0 | 0 | 1 | 3 | 4 | 0 | 2.11 |
| SP | McGowan, D.McGowan, Dustin | 27 | Blue Jays | R | 67 | 8 | 8 | 5 | 1 | 3.18 | .258 | 0.99 | 6.3 | 2.7 | 5.3 | 56.2 | 39 | 21 | 20 | 4 | 17 | 33 | 1 | 0 | 0 | 0 | 7 | 3 | 0 | 3.82 |
| SP | Patterson, J.Patterson, John # | 31 | Red Sox | R | 87 | 8 | 8 | 3 | 4 | 5.59 | .316 | 1.38 | 9.8 | 2.7 | 8.4 | 56.1 | 61 | 35 | 35 | 3 | 17 | 52 | 1 | 0 | 0 | 1 | 4 | 0 | 0 | 2.75 |
| SP | Ramirez, H.Ramirez, Horacio | 30 | Braves | L | 59 | 8 | 8 | 4 | 3 | 4.47 | .307 | 1.26 | 9.0 | 2.4 | 7.4 | 56.1 | 56 | 29 | 28 | 6 | 15 | 46 | 0 | 0 | 0 | 0 | 4 | 4 | 1 | 3.77 |
| SP | Santana, J.Santana, Johan | 30 | Twins | L | 100 | 8 | 8 | 4 | 4 | 4.23 | .297 | 1.23 | 9.2 | 2.0 | 9.7 | 55.1 | 56 | 26 | 26 | 8 | 12 | 59 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 3.51 |
| SP | Williams, J.Williams, Jerome | 28 | Giants | R | 91 | 8 | 8 | 2 | 3 | 4.23 | .275 | 1.12 | 8.0 | 2.1 | 7.7 | 55.1 | 49 | 26 | 26 | 7 | 13 | 47 | 2 | 0 | 0 | 2 | 4 | 1 | 1 | 3.71 |
| SP | Pavano, C.Pavano, Carl | 33 | Astros | R | 49 | 7 | 7 | 4 | 3 | 3.95 | .265 | 1.04 | 8.0 | 1.5 | 6.0 | 54.2 | 48 | 25 | 24 | 10 | 9 | 36 | 2 | 0 | 0 | 0 | 4 | 2 | 1 | 4.69 |
| SP | Hudson, T.Hudson, Tim | 34 | A's | R | 84 | 8 | 8 | 4 | 3 | 4.28 | .317 | 1.35 | 9.7 | 2.7 | 6.5 | 54.2 | 58 | 26 | 26 | 13 | 16 | 39 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 5.69 |
| SP | Clemens, R.Clemens, Roger | 47 | Yankees | R | 90 | 8 | 8 | 5 | 3 | 2.82 | .282 | 1.12 | 8.0 | 2.2 | 7.5 | 54.1 | 48 | 20 | 17 | 4 | 13 | 45 | 0 | 0 | 0 | 0 | 7 | 3 | 2 | 3.19 |
| SP | Schmidt, J.Schmidt, Jason | 36 | Giants | R | 93 | 8 | 8 | 6 | 1 | 2.33 | .283 | 1.15 | 7.3 | 3.0 | 8.8 | 54.0 | 44 | 17 | 14 | 7 | 18 | 53 | 1 | 0 | 0 | 0 | 7 | 2 | 0 | 3.83 |
| SP | Bush, D.Bush, David | 30 | Blue Jays | R | 69 | 8 | 8 | 4 | 3 | 3.50 | .277 | 1.09 | 6.8 | 3.0 | 6.8 | 54.0 | 41 | 21 | 21 | 8 | 18 | 41 | 0 | 0 | 0 | 0 | 6 | 3 | 2 | 4.57 |
| SP | Zito, B.Zito, Barry | 31 | Astros | L | 76 | 8 | 8 | 2 | 4 | 3.91 | .293 | 1.23 | 8.0 | 3.1 | 6.6 | 53.0 | 47 | 24 | 23 | 4 | 18 | 39 | 1 | 0 | 0 | 1 | 4 | 1 | 0 | 3.58 |
| SP | Hanson, T.Hanson, Tommy # | 22 | Braves | R | 72 | 8 | 8 | 1 | 3 | 4.61 | .269 | 1.08 | 7.1 | 2.8 | 8.1 | 52.2 | 41 | 28 | 27 | 7 | 16 | 47 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 3.92 |
| SP | Harden, R.Harden, Rich | 28 | A's | R | 98 | 8 | 8 | 3 | 1 | 2.77 | .278 | 1.13 | 7.3 | 2.9 | 5.7 | 52.0 | 42 | 16 | 16 | 2 | 17 | 33 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.27 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke | 29 | Red Sox | R | 54 | 8 | 8 | 2 | 3 | 5.02 | .358 | 1.65 | 11.4 | 3.5 | 8.5 | 52.0 | 66 | 29 | 29 | 6 | 20 | 49 | 0 | 0 | 0 | 0 | 3 | 1 | 4 | 3.83 |
| SP | Vazquez, J.Vazquez, Javier | 33 | Yankees | R | 67 | 8 | 8 | 4 | 2 | 3.46 | .307 | 1.27 | 8.3 | 3.1 | 6.1 | 52.0 | 48 | 22 | 20 | 4 | 18 | 35 | 2 | 0 | 0 | 0 | 5 | 3 | 1 | 3.87 |
| SP | Shields, J.Shields, James | 28 | Devil Rays | R | 86 | 8 | 8 | 2 | 5 | 4.01 | .289 | 1.20 | 8.6 | 2.3 | 6.5 | 51.2 | 49 | 29 | 23 | 4 | 13 | 37 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 3.39 |
| SP | Willis, D.Willis, Dontrelle | 27 | Marlins | L | 94 | 8 | 8 | 2 | 3 | 5.23 | .320 | 1.32 | 10.4 | 1.6 | 7.9 | 51.2 | 59 | 32 | 30 | 6 | 9 | 45 | 0 | 0 | 0 | 0 | 2 | 5 | 1 | 3.59 |
| SP | Villanueva, C.Villanueva, Carlos | 26 | Brewers | R | 91 | 8 | 8 | 2 | 3 | 3.14 | .276 | 1.14 | 9.0 | 1.4 | 6.2 | 51.2 | 51 | 19 | 18 | 4 | 8 | 35 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 3.12 |
| SP | Jackson, E.Jackson, Edwin | 26 | Dodgers | R | 100 | 8 | 8 | 4 | 3 | 2.96 | .282 | 1.16 | 6.4 | 4.2 | 10.1 | 51.2 | 36 | 17 | 17 | 2 | 24 | 57 | 0 | 0 | 0 | 0 | 4 | 1 | 2 | 2.75 |
| SP | Pineiro, J.Pineiro, Joel | 31 | Mariners | R | 68 | 8 | 8 | 2 | 3 | 3.86 | .300 | 1.27 | 9.4 | 2.1 | 6.4 | 51.1 | 53 | 22 | 22 | 5 | 12 | 36 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 3.63 |
| SP | Pettitte, A.Pettitte, Andy | 37 | Yankees | L | 72 | 8 | 8 | 3 | 4 | 4.94 | .323 | 1.43 | 9.7 | 3.2 | 5.6 | 51.0 | 55 | 28 | 28 | 9 | 18 | 32 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 5.10 |
| SP | Myers, B.Myers, Brett | 29 | Phillies | R | 70 | 8 | 8 | 2 | 5 | 3.55 | .280 | 1.16 | 7.6 | 3.1 | 8.5 | 50.2 | 42 | 24 | 20 | 7 | 17 | 47 | 0 | 0 | 0 | 0 | 5 | 0 | 2 | 3.96 |
| SP | Lowe, D.Lowe, Derek | 36 | Red Sox | R | 63 | 8 | 8 | 2 | 4 | 4.26 | .324 | 1.38 | 10.6 | 2.0 | 7.0 | 50.2 | 59 | 24 | 24 | 9 | 11 | 39 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 4.62 |
| SP | Sabathia, C.Sabathia, CC | 29 | Brewers | L | 79 | 8 | 8 | 1 | 7 | 4.29 | .314 | 1.33 | 9.4 | 2.7 | 7.0 | 50.1 | 52 | 26 | 24 | 4 | 15 | 39 | 2 | 0 | 0 | 0 | 4 | 2 | 0 | 3.50 |
| SP | Penny, B.Penny, Brad | 31 | Marlins | R | 74 | 7 | 7 | 5 | 1 | 3.22 | .281 | 1.13 | 8.1 | 2.2 | 7.7 | 50.1 | 45 | 18 | 18 | 8 | 12 | 43 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 4.20 |
| SP | Floyd, G.Floyd, Gavin | 26 | Phillies | R | 53 | 8 | 8 | 3 | 1 | 3.96 | .306 | 1.30 | 9.9 | 1.8 | 7.9 | 50.0 | 55 | 30 | 22 | 6 | 10 | 44 | 1 | 0 | 0 | 0 | 4 | 1 | 1 | 3.46 |
| SP | Bonser, B.Bonser, Boof | 28 | Twins | R | 48 | 8 | 8 | 1 | 2 | 4.17 | .313 | 1.35 | 9.6 | 2.8 | 5.7 | 49.2 | 52 | 24 | 23 | 4 | 15 | 31 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 3.78 |
| SP | Lincecum, T.Lincecum, Tim # | 25 | Giants | R | 96 | 8 | 8 | 2 | 4 | 6.52 | .341 | 1.53 | 10.3 | 3.7 | 9.0 | 49.2 | 56 | 36 | 36 | 10 | 20 | 49 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 4.94 |
| SP | Nolasco, R.Nolasco, Ricky # | 27 | Devil Rays | R | 82 | 8 | 8 | 5 | 2 | 5.07 | .323 | 1.39 | 10.3 | 2.4 | 5.3 | 49.2 | 56 | 32 | 28 | 9 | 13 | 29 | 1 | 0 | 0 | 0 | 5 | 2 | 0 | 5.12 |
| SP | Beckett, J.Beckett, Josh | 29 | Marlins | R | 97 | 8 | 8 | 2 | 3 | 5.55 | .342 | 1.54 | 11.3 | 2.8 | 7.3 | 48.2 | 60 | 31 | 30 | 8 | 15 | 39 | 0 | 0 | 0 | 0 | 3 | 1 | 3 | 4.54 |
| SP | Kershaw, C.Kershaw, Clayton | 21 | Dodgers | L | 71 | 8 | 8 | 2 | 2 | 3.78 | .285 | 1.15 | 7.1 | 3.4 | 8.4 | 47.2 | 37 | 20 | 20 | 7 | 18 | 44 | 1 | 0 | 0 | 0 | 5 | 2 | 1 | 4.34 |
| SP | Billingsley, C.Billingsley, Chad | 25 | Dodgers | R | 39 | 8 | 8 | 4 | 1 | 4.79 | .316 | 1.36 | 8.2 | 4.0 | 9.2 | 47.0 | 43 | 25 | 25 | 6 | 21 | 48 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 4.02 |
| SP | Sheets, B.Sheets, Ben | 31 | Brewers | R | 79 | 8 | 8 | 4 | 2 | 3.83 | .309 | 1.30 | 8.4 | 3.3 | 6.5 | 47.0 | 44 | 20 | 20 | 6 | 17 | 34 | 2 | 0 | 0 | 1 | 5 | 2 | 2 | 4.43 |
| SP | Wakefield, T.Wakefield, Tim | 43 | Red Sox | R | 60 | 7 | 7 | 2 | 1 | 4.82 | .289 | 1.20 | 8.0 | 2.9 | 5.5 | 46.2 | 41 | 26 | 25 | 4 | 15 | 28 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 3.96 |
| SP | Gallardo, Y.Gallardo, Yovani # | 23 | Brewers | R | 85 | 8 | 8 | 3 | 3 | 4.34 | .332 | 1.45 | 10.2 | 3.0 | 7.4 | 45.2 | 51 | 22 | 22 | 4 | 15 | 37 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 3.64 |
| SP | Baker, S.Baker, Scott | 28 | Twins | R | 86 | 8 | 8 | 2 | 2 | 3.20 | .318 | 1.33 | 9.6 | 2.4 | 7.6 | 45.0 | 48 | 16 | 16 | 7 | 12 | 38 | 0 | 0 | 0 | 0 | 4 | 3 | 0 | 4.33 |
| SP | Lohse, K.Lohse, Kyle | 31 | Twins | R | 46 | 7 | 7 | 2 | 4 | 7.00 | .345 | 1.58 | 12.2 | 2.0 | 7.0 | 45.0 | 61 | 36 | 35 | 8 | 10 | 35 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 4.42 |
| SP | Chen, B.Chen, Bruce | 32 | Astros | L | 77 | 8 | 8 | 2 | 3 | 5.44 | .320 | 1.34 | 7.8 | 4.5 | 6.1 | 44.2 | 38 | 27 | 27 | 10 | 22 | 30 | 0 | 0 | 0 | 0 | 4 | 3 | 0 | 6.30 |
| SP | James, C.James, Chuck | 28 | Braves | L | 75 | 8 | 8 | 3 | 4 | 3.83 | .313 | 1.34 | 9.4 | 2.9 | 8.2 | 44.2 | 46 | 21 | 19 | 2 | 14 | 40 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 2.80 |
| SP | Wang, C.Wang, Chien-Ming | 29 | Yankees | R | 64 | 8 | 8 | 3 | 2 | 3.65 | .318 | 1.35 | 9.4 | 2.9 | 5.3 | 44.1 | 46 | 21 | 18 | 4 | 14 | 26 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.09 |
| SP | Towers, J.Towers, Josh | 32 | Blue Jays | R | 61 | 8 | 8 | 2 | 1 | 3.89 | .271 | 1.07 | 7.6 | 2.0 | 5.5 | 44.0 | 37 | 19 | 19 | 6 | 10 | 27 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 4.36 |
| SP | Wolf, R.Wolf, Randy | 33 | Phillies | L | 83 | 8 | 8 | 2 | 4 | 5.52 | .343 | 1.50 | 9.6 | 3.9 | 5.7 | 44.0 | 47 | 28 | 27 | 6 | 19 | 28 | 0 | 0 | 0 | 0 | 4 | 3 | 1 | 5.00 |
| SP | Blanton, J.Blanton, Joe # | 29 | A's | R | 81 | 7 | 7 | 2 | 4 | 4.09 | .302 | 1.27 | 8.2 | 3.3 | 6.1 | 44.0 | 40 | 22 | 20 | 3 | 16 | 30 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 3.68 |
| SP | Ainsworth, K.Ainsworth, Kurt | 31 | Giants | R | 55 | 7 | 7 | 3 | 3 | 4.53 | .256 | 0.98 | 7.3 | 1.7 | 6.9 | 43.2 | 35 | 22 | 22 | 9 | 8 | 33 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 4.88 |
| SP | Meche, G.Meche, Gil | 31 | Mariners | R | 58 | 8 | 8 | 1 | 3 | 6.39 | .338 | 1.44 | 10.3 | 2.9 | 7.1 | 43.2 | 49 | 32 | 31 | 8 | 14 | 34 | 0 | 0 | 0 | 0 | 2 | 4 | 2 | 5.09 |
| SP | Halladay, R.Halladay, Roy | 32 | Blue Jays | R | 89 | 8 | 8 | 3 | 4 | 6.44 | .319 | 1.36 | 9.6 | 2.7 | 9.4 | 43.1 | 46 | 32 | 31 | 7 | 13 | 45 | 1 | 0 | 0 | 0 | 3 | 2 | 1 | 4.07 |
| SP | Kuroda, H.Kuroda, Hiroki | 34 | Dodgers | R | 34 | 8 | 8 | 3 | 4 | 4.85 | .340 | 1.48 | 10.9 | 2.6 | 6.0 | 42.2 | 51 | 23 | 23 | 6 | 12 | 28 | 0 | 0 | 0 | 0 | 3 | 3 | 3 | 4.60 |
| SP | Smoltz, J.Smoltz, John | 42 | Braves | R | 42 | 7 | 7 | 2 | 4 | 6.75 | .371 | 1.72 | 11.9 | 3.7 | 8.8 | 41.1 | 54 | 31 | 31 | 8 | 17 | 40 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 4.98 |
| SP | Gabbard, K.Gabbard, Kason | 27 | Devil Rays | L | 78 | 8 | 8 | 2 | 3 | 4.83 | .324 | 1.39 | 7.9 | 4.6 | 6.4 | 41.0 | 36 | 27 | 22 | 6 | 21 | 29 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 5.17 |
| SP | Rzepczynski, M.Rzepczynski, Marc | 23 | Blue Jays | L | 57 | 7 | 7 | 2 | 2 | 4.87 | .278 | 1.16 | 6.8 | 3.8 | 7.0 | 40.2 | 30 | 22 | 22 | 2 | 17 | 31 | 0 | 0 | 0 | 0 | 3 | 0 | 5 | 3.38 |
| RP | Mateo, J.Mateo, Julio | 32 | Mariners | R | 85 | 24 | 0 | 4 | 0 | 2.72 | .232 | 0.83 | 7.2 | 0.5 | 7.2 | 39.2 | 31 | 15 | 12 | 4 | 2 | 31 | 0 | 2 | 0 | 0 | 0 | 3 | 1 | 3.13 |
| SP | Johnson, J.Johnson, Josh | 25 | Marlins | R | 84 | 8 | 8 | 0 | 5 | 5.90 | .367 | 1.66 | 10.8 | 4.4 | 7.2 | 39.2 | 47 | 27 | 26 | 2 | 19 | 31 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 3.77 |
| SP | Liriano, F.Liriano, Francisco | 26 | Twins | L | 99 | 8 | 8 | 3 | 2 | 4.08 | .320 | 1.31 | 8.8 | 3.2 | 9.7 | 39.2 | 38 | 18 | 18 | 4 | 14 | 42 | 0 | 0 | 0 | 0 | 2 | 4 | 3 | 3.56 |
| SP | Miller, W.Miller, Wade | 33 | Astros | R | 58 | 7 | 7 | 3 | 2 | 4.15 | .320 | 1.38 | 9.5 | 3.0 | 7.6 | 39.0 | 41 | 18 | 18 | 3 | 13 | 33 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 3.38 |