| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 93 | 9 | 9 | 3 | 4 | 4.38 | .287 | 1.17 | 7.6 | 3.0 | 9.5 | 51.1 | 43 | 25 | 25 | 7 | 17 | 54 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 3.78 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 90 | 9 | 9 | 4 | 3 | 3.28 | .276 | 1.14 | 6.9 | 3.5 | 8.3 | 60.1 | 46 | 24 | 22 | 8 | 23 | 55 | 1 | 0 | 0 | 0 | 7 | 0 | 0 | 4.05 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 70 | 8 | 8 | 2 | 5 | 7.46 | .342 | 1.54 | 9.0 | 4.8 | 5.9 | 41.0 | 41 | 34 | 34 | 8 | 22 | 27 | 1 | 0 | 0 | 0 | 3 | 1 | 1 | 5.90 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 19 | 0 | 2 | 2 | 4.43 | .299 | 1.23 | 6.8 | 4.5 | 11.7 | 20.1 | 15 | 10 | 10 | 3 | 10 | 26 | 0 | 9 | 3 | 0 | 0 | 1 | 1 | 4.00 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 86 | 19 | 0 | 0 | 0 | 2.59 | .336 | 1.52 | 9.4 | 4.5 | 8.3 | 24.1 | 25 | 9 | 7 | 1 | 12 | 22 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.21 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 27 | 0 | 1 | 2 | 4.88 | .303 | 1.30 | 8.3 | 3.7 | 9.0 | 27.2 | 25 | 17 | 15 | 6 | 11 | 27 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.11 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 17 | 0 | 0 | 1 | 2.45 | .267 | 1.09 | 4.1 | 5.7 | 7.4 | 22.0 | 10 | 6 | 6 | 0 | 14 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.27 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 72 | 14 | 0 | 0 | 0 | 4.71 | .292 | 1.24 | 9.0 | 2.1 | 6.9 | 21.0 | 21 | 11 | 11 | 1 | 5 | 16 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.81 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 70 | 15 | 0 | 1 | 1 | 5.17 | .309 | 1.34 | 9.0 | 3.6 | 9.6 | 15.2 | 15 | 9 | 9 | 5 | 6 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.40 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 3 | 1 | 2 | 0 | 5.25 | .368 | 1.58 | 8.3 | 6.0 | 6.8 | 12.0 | 11 | 8 | 7 | 0 | 8 | 9 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.00 |