| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 90 | 24 | 24 | 6 | 13 | 4.57 | .308 | 1.29 | 9.2 | 2.5 | 7.2 | 171.1 | 174 | 88 | 87 | 20 | 47 | 136 | 3 | 0 | 0 | 0 | 10 | 8 | 6 | 3.89 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 90 | 23 | 23 | 11 | 7 | 4.01 | .280 | 1.14 | 8.2 | 2.0 | 9.4 | 163.2 | 149 | 77 | 73 | 21 | 37 | 171 | 3 | 0 | 0 | 1 | 11 | 5 | 0 | 3.35 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 61 | 0 | 4 | 3 | 2.35 | .256 | 1.02 | 5.8 | 3.5 | 11.3 | 72.2 | 46 | 19 | 19 | 9 | 28 | 90 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.33 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 36 | 0 | 5 | 0 | 2.43 | .213 | 0.81 | 4.5 | 2.9 | 12.4 | 40.2 | 20 | 11 | 11 | 2 | 13 | 55 | 0 | 1 | 1 | 0 | 0 | 0 | 4 | 1.88 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 26 | 0 | 2 | 0 | 1.82 | .237 | 0.89 | 6.8 | 1.5 | 8.6 | 24.2 | 18 | 5 | 5 | 3 | 4 | 23 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.33 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 11 | 0 | 0 | 1 | 7.00 | .357 | 1.56 | 10.0 | 4.0 | 7.0 | 9.0 | 10 | 7 | 7 | 4 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 8.89 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 11 | 1 | 1 | 1 | 6.05 | .342 | 1.54 | 11.2 | 2.9 | 10.1 | 41.2 | 51 | 29 | 28 | 12 | 13 | 46 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.59 |