| SP | Scherzer, M.Scherzer, Max † >> | 37 | 2021 | R | 99 | 33 | 33 | 20 | 3 | 2.13 | .245 | 0.93 | 6.5 | 1.9 | 10.6 | 219.1 | 157 | 53 | 52 | 23 | 46 | 259 | 0 | 0 | 0 | 0 | 23 | 10 | 2 | 2.77 |
| SP | Buehler, W.Buehler, Walker >> | 26 | 2021 | R | 97 | 33 | 33 | 20 | 5 | 3.15 | .273 | 1.09 | 7.1 | 2.7 | 10.9 | 217.0 | 172 | 79 | 76 | 22 | 64 | 262 | 1 | 0 | 0 | 1 | 24 | 8 | 5 | 2.90 |
| SP | Urias, J.Urias, Julio † >> | 24 | 2021 | L | 90 | 32 | 32 | 18 | 6 | 2.95 | .258 | 1.00 | 6.7 | 2.3 | 9.9 | 201.2 | 150 | 71 | 66 | 21 | 52 | 221 | 0 | 0 | 0 | 0 | 19 | 8 | 2 | 3.05 |
| SP | Kershaw, C.Kershaw, Clayton † >> | 33 | 2021 | L | 89 | 32 | 32 | 26 | 3 | 2.50 | .246 | 0.94 | 6.4 | 2.1 | 11.6 | 198.1 | 140 | 56 | 55 | 23 | 47 | 255 | 0 | 0 | 0 | 0 | 21 | 7 | 5 | 2.75 |
| SP | Darvish, Y.Darvish, Yu >> | 34 | 2021 | R | 84 | 32 | 32 | 15 | 6 | 3.51 | .314 | 1.34 | 8.4 | 3.6 | 10.3 | 179.2 | 168 | 79 | 70 | 25 | 72 | 205 | 0 | 0 | 0 | 0 | 14 | 7 | 8 | 3.85 |
| CL | Nelson, J.Nelson, Jimmy † >> | 32 | 2021 | R | 100 | 48 | 0 | 1 | 2 | 2.53 | .269 | 1.03 | 4.5 | 4.9 | 10.1 | 42.2 | 21 | 14 | 12 | 3 | 23 | 47 | 0 | 41 | 6 | 0 | 0 | 3 | 0 | 3.55 |
| RP | Sadler, C.Sadler, Casey >> | 30 | 2021 | R | 95 | 85 | 0 | 5 | 2 | 3.41 | .269 | 1.07 | 6.7 | 3.0 | 7.1 | 100.1 | 74 | 44 | 38 | 20 | 33 | 79 | 0 | 3 | 5 | 0 | 0 | 4 | 6 | 5.13 |
| RP | Treinen, B.Treinen, Blake >> | 33 | 2021 | R | 94 | 67 | 0 | 4 | 5 | 2.91 | .311 | 1.32 | 7.1 | 4.8 | 11.0 | 68.0 | 54 | 25 | 22 | 9 | 36 | 83 | 0 | 1 | 4 | 0 | 0 | 2 | 0 | 3.96 |
| RP | Jansen, K.Jansen, Kenley >> | 33 | 2021 | R | 91 | 44 | 0 | 7 | 3 | 3.05 | .287 | 1.21 | 7.0 | 4.0 | 11.4 | 41.1 | 32 | 14 | 14 | 4 | 18 | 52 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.05 |
| RP | Knebel, C.Knebel, Corey >> | 29 | 2021 | R | 90 | 35 | 0 | 4 | 1 | 1.42 | .234 | 0.92 | 5.2 | 3.2 | 11.9 | 31.2 | 18 | 5 | 5 | 1 | 11 | 41 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.84 |
| RP | Chavez, J.Chavez, Jesse >> | 38 | 2021 | R | 88 | 33 | 0 | 1 | 0 | 2.64 | .264 | 1.01 | 6.6 | 2.7 | 9.9 | 30.2 | 22 | 9 | 9 | 4 | 9 | 33 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 3.63 |
| RP | Bickford, P.Bickford, Phil >> | 25 | 2021 | R | 87 | 45 | 0 | 0 | 0 | 2.33 | .275 | 1.07 | 6.2 | 3.4 | 8.5 | 58.0 | 40 | 15 | 15 | 4 | 22 | 55 | 0 | 1 | 0 | 0 | 0 | 4 | 0 | 3.34 |