| SP | Scherzer, M.Scherzer, Max >> | 39 | 2021 | R | 93 | 15 | 15 | 4 | 6 | 4.00 | .250 | 0.99 | 7.2 | 1.7 | 9.3 | 90.0 | 72 | 40 | 40 | 10 | 17 | 93 | 1 | 0 | 0 | 1 | 8 | 1 | 1 | 2.98 |
| SP | Lopez, R.Lopez, Reynaldo >> | 28 | 2016 | R | 90 | 15 | 15 | 5 | 4 | 4.63 | .313 | 1.36 | 8.5 | 3.8 | 8.5 | 79.2 | 75 | 42 | 41 | 12 | 33 | 75 | 0 | 0 | 0 | 0 | 8 | 1 | 5 | 4.37 |
| SP | Strasburg, S.Strasburg, Stephen >> | 34 | 2017 | R | 81 | 15 | 15 | 7 | 5 | 4.16 | .288 | 1.15 | 7.5 | 2.9 | 6.2 | 93.0 | 77 | 44 | 43 | 9 | 30 | 64 | 3 | 0 | 0 | 1 | 9 | 6 | 0 | 4.04 |
| RP | Doolittle, S.Doolittle, Sean >> | 36 | 2018 | L | 85 | 45 | 0 | 2 | 0 | 4.93 | .290 | 1.23 | 8.3 | 2.8 | 8.5 | 38.1 | 35 | 23 | 21 | 3 | 12 | 36 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.08 |
| RP | Rivero, F.Rivero, Felipe >> | 30 | 2016 | L | 75 | 32 | 0 | 2 | 1 | 4.66 | .320 | 1.41 | 9.6 | 3.1 | 8.4 | 29.0 | 31 | 18 | 15 | 5 | 10 | 27 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.41 |
| RP | Romero, E.Romero, Enny >> | 32 | 2017 | L | 69 | 22 | 0 | 1 | 1 | 6.46 | .370 | 1.76 | 11.4 | 4.8 | 7.2 | 15.1 | 19 | 11 | 11 | 2 | 8 | 12 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 4.73 |
| RP | Machado, A.Machado, Andres >> | 30 | 2021 | R | 67 | 53 | 0 | 0 | 5 | 4.33 | .336 | 1.52 | 6.9 | 6.8 | 5.5 | 52.0 | 40 | 30 | 25 | 4 | 39 | 32 | 0 | 1 | 4 | 0 | 0 | 0 | 3 | 5.02 |
| RP | Herrera, K.Herrera, Kelvin >> | 33 | 2018 | R | 59 | 46 | 0 | 4 | 3 | 6.58 | .320 | 1.41 | 10.4 | 2.5 | 5.5 | 39.2 | 45 | 30 | 29 | 6 | 11 | 24 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 4.62 |
| RP | Harvey, H.Harvey, Hunter >> | 28 | 2022 | R | 52 | 34 | 0 | 0 | 3 | 4.13 | .315 | 1.38 | 8.4 | 4.2 | 10.4 | 32.2 | 30 | 15 | 15 | 4 | 15 | 37 | 0 | 4 | 1 | 0 | 0 | 0 | 2 | 3.72 |
| SP | Corbin, P.Corbin, Patrick >> | 33 | 2019 | L | 51 | 6 | 0 | 0 | 3 | 8.31 | .519 | 3.00 | 22.5 | 6.8 | 9.0 | 4.1 | 10 | 4 | 4 | 1 | 3 | 4 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 7.25 |