| SP | Buchholz, C.Buchholz, Clay >> | 28 | 2010 | R | 58 | 9 | 9 | 4 | 3 | 5.43 | .325 | 1.43 | 9.5 | 3.5 | 7.5 | 54.2 | 57 | 33 | 33 | 10 | 21 | 45 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 4.96 |
| SP | Arroyo, B.Arroyo, Bronson >> | 35 | 2010 | R | 47 | 9 | 9 | 4 | 3 | 4.03 | .301 | 1.26 | 9.8 | 1.6 | 6.7 | 58.0 | 63 | 26 | 26 | 8 | 10 | 43 | 1 | 0 | 0 | 1 | 7 | 2 | 2 | 3.93 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 32 | 2007 | R | 38 | 9 | 9 | 4 | 5 | 4.66 | .351 | 1.53 | 9.3 | 4.5 | 7.3 | 58.0 | 60 | 34 | 30 | 6 | 29 | 47 | 0 | 0 | 0 | 0 | 4 | 5 | 2 | 4.48 |
| SP | Wakefield, T.Wakefield, Tim >> | 46 | 2008 | R | 24 | 9 | 9 | 3 | 3 | 5.01 | .329 | 1.45 | 9.0 | 4.1 | 6.5 | 50.1 | 50 | 28 | 28 | 3 | 23 | 36 | 0 | 0 | 0 | 0 | 5 | 1 | 3 | 3.78 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 32 | 2006 | R | 97 | 18 | 0 | 1 | 4 | 4.00 | .260 | 1.00 | 7.5 | 1.5 | 9.5 | 18.0 | 15 | 8 | 8 | 1 | 3 | 19 | 0 | 11 | 1 | 0 | 0 | 1 | 0 | 2.28 |
| SU | Delcarmen, M.Delcarmen, Manny >> | 30 | 2007 | R | 95 | 15 | 0 | 0 | 0 | 2.33 | .266 | 1.09 | 6.2 | 3.8 | 12.3 | 19.1 | 13 | 5 | 5 | 2 | 8 | 26 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 2.89 |
| RP | Masterson, J.Masterson, Justin >> | 27 | 2008 | R | 77 | 20 | 0 | 2 | 0 | 3.44 | .290 | 1.20 | 8.0 | 3.0 | 7.5 | 36.2 | 32 | 14 | 14 | 2 | 12 | 30 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.14 |
| RP | Tazawa, J.Tazawa, Junichi >> | 26 | 2012 | R | 70 | 16 | 0 | 1 | 0 | 6.08 | .394 | 1.95 | 14.5 | 3.5 | 11.8 | 13.1 | 21 | 9 | 9 | 2 | 5 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.54 |
| RP | Miller, A.Miller, Andrew >> | 27 | 2012 | L | 54 | 13 | 0 | 0 | 0 | 6.39 | .367 | 1.66 | 7.5 | 8.3 | 11.3 | 12.2 | 10 | 9 | 9 | 0 | 11 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.50 |