| CL | Doolittle, S.Doolittle, Sean † | Red Sox | L | 138.5 | 67 | 0 | 8 | 6 | 3.28 | .279 | 1.16 | 7.9 | 2.7 | 10.1 | 71.1 | 62 | 26 | 26 | 14 | 21 | 80 | 0 | 39 | 6 | 0 | 0 | 0 | 1 | 4.20 |
| SP | Kershaw, C.Kershaw, Clayton † | First Pick | L | 138.0 | 33 | 33 | 17 | 14 | 3.24 | .278 | 1.14 | 8.3 | 2.0 | 10.1 | 249.2 | 230 | 94 | 90 | 29 | 55 | 280 | 8 | 0 | 0 | 2 | 22 | 4 | 6 | 2.98 |
| RP | Kimbrel, C.Kimbrel, Craig † | Warriors | R | 130.0 | 89 | 0 | 13 | 4 | 1.94 | .245 | 0.96 | 4.9 | 3.7 | 11.5 | 116.0 | 63 | 26 | 25 | 10 | 48 | 148 | 0 | 10 | 3 | 0 | 0 | 2 | 9 | 2.86 |
| SP | Tanana, F.Tanana, Frank # | Trojans | L | 125.0 | 28 | 28 | 17 | 6 | 3.94 | .293 | 1.23 | 7.8 | 3.3 | 7.1 | 217.0 | 187 | 100 | 95 | 28 | 79 | 170 | 12 | 0 | 0 | 1 | 17 | 4 | 4 | 4.26 |
| SP | deGrom, J.deGrom, Jacob # $ | Red Sox | R | 125.0 | 33 | 33 | 15 | 8 | 3.03 | .255 | 1.01 | 6.8 | 2.3 | 10.4 | 208.0 | 158 | 71 | 70 | 35 | 52 | 240 | 1 | 0 | 0 | 0 | 24 | 4 | 0 | 3.69 |
| CL | Street, H.Street, Huston † $ | CRACKERS | R | 114.0 | 64 | 0 | 5 | 4 | 2.90 | .270 | 1.11 | 6.6 | 3.4 | 9.0 | 71.1 | 52 | 23 | 23 | 10 | 27 | 71 | 0 | 32 | 4 | 0 | 0 | 0 | 1 | 3.97 |